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Chang, Eugene B.
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overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/
One or more keywords matched the following items that are connected to Chang, Eugene B.
Item TypeName
Concept Sodium-Potassium-Exchanging ATPase
Concept Bile Acids and Salts
Concept Amino Acid Sequence
Concept Antigens, Surface
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Anastomosis, Surgical
Concept Computer Simulation
Concept Base Sequence
Concept Bacillus subtilis
Concept Binding Sites
Concept Immune System
Concept Drug Synergism
Concept Mass Screening
Concept Digestive System Diseases
Concept Cross-Sectional Studies
Concept Disease Susceptibility
Concept Muscle, Smooth
Concept Galvanic Skin Response
Concept Genes, Bacterial
Concept Nutritional Status
Concept Hypertonic Solutions
Concept Immune System Diseases
Concept Length of Stay
Concept Lymphatic System
Concept Home Care Services
Concept Mice, Inbred Strains
Concept Organ Size
Concept Molecular Sequence Data
Concept Heat-Shock Proteins
Concept Selenium
Concept Shock
Concept Shock, Septic
Concept Sodium Salicylate
Concept Spermine
Concept Stimulation, Chemical
Concept Stress, Physiological
Concept Magnetic Resonance Spectroscopy
Concept Sulfhydryl Compounds
Concept Sulfones
Concept Surface-Active Agents
Concept Receptors, Cell Surface
Concept Salmonella
Concept Intestinal Secretions
Concept Intestine, Small
Concept Short Bowel Syndrome
Concept Sleep Deprivation
Concept Somatostatin
Concept Species Specificity
Concept Safflower Oil
Concept Serpins
Concept Sodium
Concept Solubility
Concept Sulfasalazine
Concept Salmonella Infections
Concept Salmonella typhimurium
Concept Serotonin
Concept Steroid Hydroxylases
Concept Sensitivity and Specificity
Concept Mass Spectrometry
Concept Substance Withdrawal Syndrome
Concept Swine
Concept Skin
Concept Sucrase-Isomaltase Complex
Concept Sulfates
Concept Sulfites
Concept Surgical Procedures, Operative
Concept Surgical Wound Infection
Concept Superoxides
Concept Symbiosis
Concept Sodium Radioisotopes
Concept Software
Concept Specific Pathogen-Free Organisms
Concept Stem Cells
Concept Stomach
Concept Genome
Concept United States
Concept Vascular Surgical Procedures
Concept Syndrome
Concept Sodium-Hydrogen Exchangers
Concept Protein Structure, Quaternary
Concept Electrophoretic Mobility Shift Assay
Concept Genome, Bacterial
Concept Carotid Stenosis
Concept Second Messenger Systems
Concept Rats, Sprague-Dawley
Concept Mutagenesis, Site-Directed
Concept Case-Control Studies
Concept Dextran Sulfate
Concept Sus scrofa
Concept Alternative Splicing
Concept In Situ Hybridization
Concept Sequence Analysis, DNA
Concept Prostate-Specific Antigen
Concept Protein Structure, Tertiary
Concept Genes, Reporter
Concept Microscopy, Electron, Scanning
Concept Myelin Sheath
Concept Receptors, Serotonin, 5-HT3
Concept Serotonin Plasma Membrane Transport Proteins
Concept HSP70 Heat-Shock Proteins
Concept Oxidative Stress
Concept Muscle, Skeletal
Concept Sodium-Glucose Transporter 1
Concept Sepsis
Concept Transgenes
Concept Dietary Sucrose
Concept Calcium Signaling
Concept Metabolic Syndrome
Concept Sodium-Bicarbonate Symporters
Concept Reactive Oxygen Species
Concept Protein Structure, Secondary
Concept Adaptor Protein Complex mu Subunits
Concept Shear Strength
Concept Biodiversity
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Paranasal Sinuses
Concept Oligonucleotide Array Sequence Analysis
Concept Branchio-Oto-Renal Syndrome
Concept Small Ubiquitin-Related Modifier Proteins
Concept Catalytic Domain
Concept STAT3 Transcription Factor
Concept SUMO-1 Protein
Concept Interleukin-11 Receptor alpha Subunit
Concept Rats, Inbred Strains
Concept Receptors, Steroid
Concept Respiratory System
Concept HSP27 Heat-Shock Proteins
Concept Severity of Illness Index
Concept Tandem Mass Spectrometry
Concept Myocytes, Smooth Muscle
Concept Saponins
Concept Ribosomal Protein S6 Kinases, 90-kDa
Concept Sodium Chloride
Concept Specimen Handling
Concept Streptomycin
Concept Structure-Activity Relationship
Concept Substance P
Concept Sucrase
Concept High-Throughput Screening Assays
Concept TOR Serine-Threonine Kinases
Concept High-Throughput Nucleotide Sequencing
Concept Sex Factors
Concept Sigmoidoscopy
Concept Sinusitis
Concept Skin Neoplasms
Concept Mitochondrial Size
Concept Spores, Bacterial
Concept Staphylococcus aureus
Concept Streptozocin
Concept Subcellular Fractions
Concept Adaptor Proteins, Signal Transducing
Concept Sucrose
Concept Sympathectomy, Chemical
Concept Synaptotagmin I
Concept Survival Analysis
Concept Genes, myc
Concept Vascular System Injuries
Concept Patient Satisfaction
Concept Genome, Human
Concept Skin Transplantation
Concept Lymphocyte Subsets
Concept Cellular Senescence
Concept Thiobarbituric Acid Reactive Substances
Concept Dietary Supplements
Concept Spectrometry, Mass, Electrospray Ionization
Concept Muscle Fibers, Skeletal
Concept Home Care Services, Hospital-Based
Concept HSP90 Heat-Shock Proteins
Concept Nitric Oxide Synthase
Concept Sodium-Calcium Exchanger
Concept MAP Kinase Signaling System
Concept Sirtuins
Concept Extracellular Signal-Regulated MAP Kinases
Concept Bariatric Surgery
Concept Nuclear Receptor Subfamily 2, Group C, Member 1
Concept Transcriptome
Concept Solid Phase Extraction
Concept Nod2 Signaling Adaptor Protein
Concept Insulin Receptor Substrate Proteins
Concept RNA, Small Interfering
Concept Cord Blood Stem Cell Transplantation
Concept Pulmonary Surfactant-Associated Protein A
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Size
Concept STAT6 Transcription Factor
Concept Protein Inhibitors of Activated STAT
Concept HSP72 Heat-Shock Proteins
Concept Nitric Oxide Synthase Type III
Concept Metagenome
Concept Protein Stability
Concept Sumoylation
Concept Wnt Signaling Pathway
Concept Cell Survival
Concept Colorectal Surgery
Concept Drug Screening Assays, Antitumor
Concept Follow-Up Studies
Concept Growth Substances
Concept Longitudinal Studies
Concept Malabsorption Syndromes
Concept Mice, Mutant Strains
Concept Organ Specificity
Concept Prospective Studies
Concept Proto-Oncogenes
Concept Retrospective Studies
Concept Semiconductors
Concept Signal Transduction
Concept Tumor Suppressor Protein p53
Concept Sequence Analysis, RNA
Concept Superantigens
Concept Heat-Shock Response
Concept E-Selectin
Concept RNA Stability
Concept Symporters
Concept Intracellular Space
Concept Irritable Bowel Syndrome
Concept Macromolecular Substances
Concept Quorum Sensing
Concept Sirtuin 1
Academic Article Bethanechol inhibition of chicken intestinal brush border Na/H exchange: role of protein kinase C and other calcium-dependent processes.
Academic Article Endotoxin-induced alterations in rat colonic water and electrolyte transport.
Academic Article Differential function of intestinal intraepithelial lymphocyte subsets.
Academic Article Characterization of chicken intestinal brush border membrane Na/H exchange.
Academic Article Inhibition of glycosylation decreases Na+/H+ exchange activity, blocks NHE-3 transport to the membrane, and increases NHE-3 mRNA expression in LLC-PK1 cells.
Academic Article Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte.
Academic Article Glycosylation of the Na+/H+ exchanger isoform NHE-3 is species specific.
Academic Article Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus.
Academic Article Tissue distribution of Na+/H+ exchanger isoforms NHE2 and NHE4 in rat intestine and kidney.
Academic Article Intestinal water and electrolyte absorption and secretion.
Academic Article Heat-shock protein 72 protects against oxidant-induced injury of barrier function of human colonic epithelial Caco2/bbe cells.
Academic Article Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport.
Academic Article Regulation of intestinal epithelial brush border Na(+)/H(+) exchanger isoforms, NHE2 and NHE3, in C2bbe cells.
Academic Article Glutamine protects intestinal epithelial cells: role of inducible HSP70.
Academic Article Biosynthesis and cell surface delivery of the NHE1 isoform of Na+/H+ exchanger in A6 cells.
Academic Article Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells.
Academic Article An avian sodium-hydrogen exchanger.
Academic Article Inverse relationship between membrane lipid fluidity and activity of Na+/H+ exchangers, NHE1 and NHE3, in transfected fibroblasts.
Academic Article A unique Na+/H+ exchanger, analogous to NHE1, in the chicken embryonic fibroblast.
Academic Article Epithelial secretory response to inflammation.
Academic Article Phorbol ester inhibition of chicken intestinal brush-border sodium-proton exchange.
Academic Article Calcium mediated neurohumoral inhibition of chicken enterocyte Na influx: role of phosphatidylinositol metabolites.
Academic Article Altered regulation of regional sucrase-isomaltase expression in diabetic rat intestine.
Academic Article Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa.
Academic Article Glutamine induces heat shock protein and protects against endotoxin shock in the rat.
Academic Article Chemotactic peptide effects on intestinal electrolyte transport.
Academic Article Oxidants potentiate Ca(2+)- and cAMP-stimulated Cl(-) secretion in intestinal epithelial T84 cells.
Academic Article Cell-specific induction of hsp72-mediated protection by glutamine against oxidant injury in IEC18 cells.
Academic Article Dexamethasone protection of rat intestinal epithelial cells against oxidant injury is mediated by induction of heat shock protein 72.
Academic Article Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells.
Academic Article Ca-mediated stimulation of Cl secretion by reactive oxygen metabolites in human colonic T84 cells.
Academic Article Regional alterations in intestinal sucrase expression in streptozocin-treated chronically diabetic rats.
Academic Article SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells.
Academic Article Interleukins 1 and 3 stimulate anion secretion in chicken intestine.
Academic Article Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells.
Academic Article Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia.
Academic Article Inhibition of Na+,K+-ATPase by interferon gamma down-regulates intestinal epithelial transport and barrier function.
Academic Article Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation.
Academic Article Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection.
Academic Article Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress.
Academic Article Cystic fibrosis transmembrane regulator mRNA expression relative to ion-nutrient transport in spontaneously differentiating human intestinal CaCo-2 epithelial cells.
Academic Article Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function.
Academic Article Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic.
Academic Article Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction.
Academic Article Heat shock protein 72 binds and protects dihydrofolate reductase against oxidative injury.
Academic Article T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.
Academic Article IFN-gamma downregulates expression of Na(+)/H(+) exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells.
Academic Article High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa.
Academic Article Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity.
Academic Article Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.
Academic Article Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells.
Academic Article Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells.
Academic Article Recognition of host immune activation by Pseudomonas aeruginosa.
Academic Article Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72.
Academic Article AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins.
Academic Article Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells.
Academic Article Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa.
Academic Article This month in gastroenterology.
Academic Article Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption.
Academic Article Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa.
Academic Article Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine.
Academic Article Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure.
Academic Article Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium.
Academic Article Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.
Academic Article fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection.
Academic Article Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.
Academic Article Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.
Academic Article Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation.
Academic Article The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review.
Academic Article Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity.
Academic Article Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation.
Academic Article hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells.
Academic Article The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter.
Academic Article Acid secretion by parietal cells: relative roles for [Ca2+]i and protein kinase C.
Academic Article Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum.
Academic Article Utilization of the delay phenomenon improves blood flow and reduces collagen deposition in esophagogastric anastomoses.
Academic Article The pharmacological modification of secretory responses.
Academic Article Determinants of regional sucrase-isomaltase expression in adult rat small intestine.
Academic Article Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide.
Academic Article Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Academic Article Role and regulation of intestinal epithelial heat shock proteins in health and disease.
Academic Article Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Academic Article Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells.
Academic Article Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.
Academic Article Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa.
Academic Article Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells.
Academic Article Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis.
Academic Article Inhibition of cholera-toxin-stimulated intestinal secretion by CGS 9343B in rats: a specific calmodulin inhibitor.
Academic Article Cytokine regulation of OCTN2 expression and activity in small and large intestine.
Academic Article Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin.
Academic Article Phorbol ester-stimulated secretion in chicken ileum: role of arachidonic acid metabolism.
Academic Article Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon.
Academic Article Intestinal electrolyte transport and diarrheal disease (1).
Academic Article Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.
Academic Article 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis.
Academic Article The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer.
Academic Article Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model.
Academic Article Standard colonic lavage alters the natural state of mucosal-associated microbiota in the human colon.
Academic Article Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.
Academic Article Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer.
Academic Article Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma.
Academic Article Increased Likelihood of Bacterial Pathogens in the Coronal Sulcus and Urethra of Uncircumcised Men in a Diverse Group of HIV Infected and Uninfected Patients in India.
Academic Article Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Academic Article Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha.
Academic Article Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response.
Academic Article miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
Academic Article Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells.
Academic Article Enterocyte alpha 2-adrenergic receptors: yohimbine and p-aminoclonidine binding relative to ion transport.
Academic Article Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function.
Academic Article Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitis.
Academic Article American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article Glucose enhancement of transcellular calcium transport in the intestine.
Academic Article In vitro effects of the long-acting somatostatin analogue SMS 201-995 on electrolyte transport by the rabbit ileum.
Academic Article Diarrhea in streptozocin-treated rats. Loss of adrenergic regulation of intestinal fluid and electrolyte transport.
Academic Article Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.
Academic Article A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.
Academic Article Effect of high osmolality on Na+/H+ exchange in renal proximal tubule cells.
Academic Article Na+/H+ exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization.
Academic Article Effect of glucose on calcium transport in rat duodenum.
Academic Article Phorbol ester inhibition of Na-H exchange in rabbit proximal colon.
Academic Article Salmonella bacterial adherence and penetration of mucosal cells: inducing role of the epithelium.
Academic Article A model for gastric banding in the treatment of morbid obesity: the effect of chronic partial gastric outlet obstruction on esophageal physiology.
Academic Article Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection.
Academic Article NHE-1 isoform of the Na+/H+ antiport is expressed in the rat and rabbit esophagus.
Academic Article An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats.
Academic Article Experimental diabetic diarrhea in rats. Intestinal mucosal denervation hypersensitivity and treatment with clonidine.
Academic Article Intestinal adaptation to diabetes. Altered Na-dependent nutrient absorption in streptozocin-treated chronically diabetic rats.
Academic Article Calcium-mediated cyclic AMP inhibition of Na-H exchange in small intestine.
Academic Article Expression and phosphorylation of NHE1 in wild-type and transformed human and rodent fibroblasts.
Academic Article Localization of the Na+/H+ exchanger isoform NHE-3 in rabbit and canine kidney.
Academic Article Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Academic Article The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away.
Academic Article Do heat shock proteins play any role in gut inflammation?
Academic Article Differential regulation of Na+/H+ exchange and H(+)-ATPase by pH and HCO3- in kidney proximal tubules.
Academic Article Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon.
Academic Article PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
Academic Article Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward.
Academic Article Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicylic acid.
Academic Article Differentiation of rat small intestinal epithelial cells by extracellular matrix.
Academic Article Phorbol ester stimulation of active anion secretion in intestine.
Academic Article Treatment of diabetic diarrhea with clonidine.
Academic Article Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury.
Academic Article Glucocorticoids regulate Na+/H+ exchange expression and activity in region- and tissue-specific manner.
Academic Article Small intestine hexose transport in experimental diabetes. Increased transporter mRNA and protein expression in enterocytes.
Academic Article Phorbol dibutyrate-specific protein phosphorylation in brush border membranes of chicken enterocytes.
Academic Article Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon.
Academic Article Regulation of apical membrane Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cell line C2/bbe.
Academic Article The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis.
Academic Article Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells.
Academic Article Anti-apoptotic effects of L-glutamine-mediated transcriptional modulation of the heat shock protein 72 during heat shock.
Academic Article Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor.
Academic Article Protein kinase C unleashed.
Academic Article Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells.
Academic Article Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3.
Academic Article Intestinal electrolyte transport and diarrheal disease (2)
Academic Article Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.
Academic Article Effects of serotonin on Na+-H+ exchange and intracellular calcium in isolated chicken enterocytes.
Academic Article Effect of the thiol-oxidizing agent diamide on NH2Cl-induced rat colonic electrolyte secretion.
Academic Article Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells.
Academic Article EUS characteristics of Nissen fundoplication: normal appearance and mechanisms of failure.
Academic Article Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells.
Academic Article Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Academic Article Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity.
Academic Article Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions.
Academic Article Requirements for ion and solute transport, and pH regulation during enamel maturation.
Academic Article SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes.
Academic Article Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases.
Academic Article Targeting vaccinia to solid tumors with local hyperthermia.
Academic Article Serum uric Acid as a predictor for the development of nonalcoholic Fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study.
Academic Article p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Academic Article Parathyroid hormone suppresses insulin signaling in adipocytes.
Academic Article Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells.
Academic Article Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
Academic Article Fresh perspectives in chronic constipation and other functional bowel disorders.
Academic Article 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes.
Academic Article Dietary intervention with vitamin D, calcium, and whey protein reduced fat mass and increased lean mass in rats.
Academic Article Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.
Academic Article MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation.
Academic Article Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Academic Article A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Academic Article Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice.
Academic Article Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota.
Academic Article Functional predictions from inference and observation in sequence-based inflammatory bowel disease research.
Academic Article De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.
Academic Article Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
Academic Article Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening.
Academic Article TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression.
Academic Article Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants.
Academic Article Commensal bacteria protect against food allergen sensitization.
Academic Article Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection.
Academic Article Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.
Academic Article Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
Academic Article The microbial basis of inflammatory bowel diseases.
Academic Article Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects.
Academic Article Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
Academic Article Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa.
Academic Article Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].
Academic Article Michael Field, MD (1933-2014).
Academic Article The role of diet in triggering human inflammatory disorders in the modern age.
Academic Article Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.
Academic Article Nutrition, microbiomes, and intestinal inflammation.
Academic Article The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013.
Award or Honor Receipt Takeda Distinguished Scientist Award
Academic Article Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation.
Academic Article Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model.
Academic Article Intracellular HMGB1: defender of client proteins and cell fate.
Academic Article Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC).
Academic Article Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.
Academic Article Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.
Academic Article Neuroprotective interventions: is it too late?
Academic Article New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis.
Academic Article Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis.
Academic Article Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article Adiponectin deletion impairs insulin signaling in insulin-sensitive but not insulin-resistant 3T3-L1 adipocytes.
Academic Article Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
Academic Article Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression.
Academic Article Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injury.
Academic Article Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.
Academic Article Restoration of adiponectin expression via the ERK pathway in TNFa-treated 3T3-L1 adipocytes.
Academic Article Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells.
Academic Article Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
Academic Article Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids.
Academic Article Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome.
Academic Article Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model.
Academic Article Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Academic Article Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K.
Academic Article Ezetimibe stimulates intestinal glucagon-like peptide 1 secretion via the MEK/ERK pathway rather than dipeptidyl peptidase 4 inhibition.
Academic Article Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.
Academic Article Common problems in critically ill obstetric patients, with an emphasis on pharmacotherapy.
Academic Article Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice.
Academic Article New insights into the pathogenesis of cystic fibrosis sinusitis.
Academic Article Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.
Academic Article Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Academic Article Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.
Academic Article Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.
Academic Article Precision Genomic Medicine in Cystic Fibrosis.
Academic Article Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats.
Academic Article Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells.
Academic Article Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer.
Academic Article Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.
Academic Article Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota.
Academic Article Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.
Academic Article Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Academic Article The Gut Microbiota: The Gateway to Improved Metabolism.
Academic Article Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.
Academic Article Patient-Specific Bacteroides Genome Variants in Pouchitis.
Academic Article O-014 Bacterial Sensor NOD2 Deletion Causes Th2-Inflammatory Bowel Disease Improvement Without Inducing Acute Metatranscriptomic Dysbiosis in Mice.
Academic Article Evolutionary and ecological forces that shape the bacterial communities of the human gut.
Academic Article Kinase-SUMO networks in diabetes-mediated cardiovascular disease.
Academic Article Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis.
Academic Article Krüppel-like factors in endothelial cell biology.
Academic Article Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.
Academic Article Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes.
Academic Article Microbial metabolites in health and disease: Navigating the unknown in search of function.
Academic Article A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade.
Academic Article Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway.
Academic Article Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes.
Academic Article Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].
Academic Article Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Academic Article Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues.
Academic Article Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome.
Academic Article Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption.
Academic Article Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.
Academic Article Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.
Academic Article Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2.
Academic Article Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats.
Academic Article Factors affecting hospital length of stay following pelvic exenteration surgery.
Academic Article Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Academic Article The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.
Academic Article Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Academic Article Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues.
Academic Article Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100).
Academic Article Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts.
Academic Article Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.
Academic Article Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome.
Academic Article Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.
Academic Article Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes.
Academic Article Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis.
Academic Article Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats.
Academic Article Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy.
Academic Article Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR).
Academic Article Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Academic Article Responsible stewardship for communicating microbiome research to the press and public.
Academic Article Development, implementation, and effects of a cancer center's exercise-oncology program.
Academic Article Regional Diversity of the Gastrointestinal Microbiome.
Academic Article Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury.
Academic Article Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Academic Article Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.
Academic Article Aerobic capacity attainment and reasons for cardiopulmonary exercise test termination in people with cancer: a descriptive, retrospective analysis from a single laboratory.
Academic Article TGR5 signaling mitigates parenteral nutrition-associated liver disease.
Academic Article Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty.
Academic Article Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling.
Academic Article Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells.
Academic Article Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial.
Academic Article Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes.
Academic Article Authors' Response: The three faces of Takotsubo cardiomyopathy in a single patient.
Academic Article Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article CaRE @ Home: Pilot Study of an Online Multidimensional Cancer Rehabilitation and Exercise Program for Cancer Survivors.
Academic Article "This is my home-based exercise": exploring environmental influences on home-based exercise participation in oncology.
Academic Article Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study.
Academic Article Development and Validation of a Risk Model for Breast Cancer-Related Lymphedema.
Academic Article Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned.
Academic Article Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Academic Article A Neutralizing Antibody-Conjugated Photothermal Nanoparticle Captures and Inactivates SARS-CoV-2.
Academic Article Collaborative validation of the QuEChERS procedure for the determination of pesticides in food by LC-MS/MS.
Academic Article The Gut Microbiome: Reaching the Promise Through Discovery- Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine.
Academic Article Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes.
Academic Article The microbiome: Composition and locations.
Academic Article Nanotraps for the containment and clearance of SARS-CoV-2.
Academic Article Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism.
Academic Article Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier.
Academic Article Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization.
Academic Article High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota.
Academic Article Chrysanthemum morifolium Flower Extract Ameliorates Obesity-Induced Inflammation and Increases the Muscle Mitochondria Content and AMPK/SIRT1 Activities in Obese Rats.
Academic Article A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2.
Academic Article Gut microbiota-driven brain Aß amyloidosis in mice requires microglia.
Academic Article Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch-Anal Anastomosis in Pediatric Ulcerative Colitis.
Academic Article Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis.
Academic Article The regulatory role of N6 -methyladenosine modification in the interaction between host and microbes.
Academic Article Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome.
Academic Article Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization.
Academic Article Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-?B/AMPK Activation in Obese Mice Fed a High-Fat Diet.
Academic Article Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model.
Concept Solute Carrier Family 22 Member 5
Concept Dietary Sugars
Concept Proof of Concept Study
Concept Sodium-Hydrogen Exchanger 3
Concept Myristoylated Alanine-Rich C Kinase Substrate
Concept Heat Shock Transcription Factors
Concept Spike Glycoprotein, Coronavirus
Concept SLC4A Proteins
Academic Article Sel1-like proteins and peptides are the major Oxalobacter formigenes-derived factors stimulating oxalate transport by human intestinal epithelial cells.
Academic Article Novel role of surfactant protein A in bacterial sinusitis.
Academic Article Western Diet-induced Transcriptional Changes in Anastomotic Tissue Is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery.
Academic Article Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Academic Article The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis.
Academic Article Oral Metformin Inhibits Choroidal Neovascularization by Modulating the Gut-Retina Axis.
Academic Article Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient.
Academic Article Microbially catalyzed conjugation of GABA and tyramine to bile acids.
Academic Article Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
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